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Since a physician assistant needs to be good with numbers and understand how the human body works, anyone interested in this job can begin preparing in high school by taking math and science classes, such as biology and chemistry, as well as health classes. English and social science classes, such as psychology, will also help you improve your communication skills and give you an understanding of people. Acceptance to a PA school is extremely rigorous. Get in the habit while in high school of earning high grades.