Gilead Sciences has biotech balms for infectious diseases, including hepatitis, HIV, and infections related to AIDS. The company's HIV franchise includes Truvada, a combination of two of its other drugs, Viread and Emtriva. It co-promotes another HIV treatment, called Atripla, in the US and Europe with Bristol-Myers Squibb (BMS). Other products on the market include AmBisome, used to treat systemic fungal infections such as those that accompany AIDS or kidney disease; and hepatitis B antiviral Hepsera. Beyond HIV/AIDS, Gilead also markets cardiovascular drugs Letairis and Ranexa, as well as respiratory and ophthalmic medicines.


Gilead primarily focuses on producing treatments for HIV, liver diseases including hepatitis B and hepatitis C, cancer and inflammation, and cardiovascular and respiratory conditions. Although the company is steadily working to expand in medicines in various fields, its main source of revenue continues to be its antiviral franchise, which contributes more than 90% of product sales and primarily consists of HIV medications.

Aside from the Atripla partnership with BMS, Gilead has collaborations with other companies including Japan Tobacco , which promotes HIV drugs Truvada, Viread, and Emtriva in Japan; and with GlaxoSmithKline , which markets Hepsera, Viread, and Volbris in select international markets. Additionally, Gilead Sciences receives royalties on influenza treatment Tamiflu, which it developed with Roche , and on Macugen, an ophthalmologic drug developed by Eyetech using Gilead's technology. In addition to distributing AmBisome in Canada and the US, Astellas pays royalties on US sales of Lexiscan, which is used in stress tests for coronary artery disease.

Gilead continues to advance its R&D pipeline; the company had some 180 active clinical studies at the end of 2015. It has more than 50 trials in Phase III.

The company's portfolio of 20 marketed products contains a number of firsts, such as the first complete treatment regimens for HIV and chronic hepatitis C available in a once-daily single pill.

Geographic Reach

The US market accounts for some 65% of Gilead's annual revenues. The company operates in more than 30 countries worldwide, with a significant presence in Europe (France, the UK, Spain, Italy, Germany, and Switzerland); Europe accounts for about 25% of its annual revenue. Gilead also operates in Africa, South America, and the Asia/Pacific region.

Gilead has R&D facilities in Oceanside and Fremont, California; Alberta; and Seattle. It has manufacturing sites in San Dimas, California; and Cork, Ireland. Commercial operations are located in 20 offices throughout Europe, 10 in North America, seven in Asia, two in South America, and one each in the Middle East, Australia, and Africa.

Sales and Marketing

Gilead promotes its antiviral drugs through its own commercial infrastructure in North America, some European and Asian countries, and in Australia and New Zealand; products are promoted through third-party distributors and partnerships in other regions. Gilead sells and distributes products including Atripla, Sovaldi, and Viread exclusively through wholesale channels in the US; Letairis and Cayston are distributed through specialty pharmacies. Customers include physicians, hospitals, clinics, and other health care facilities. The company's product distribution processes are handled primarily by wholesalers, including McKesson , (24% of revenue), AmerisourceBergen (19%), and Cardinal Health (15%).

In 2015 Gilead spent $601 million on advertising, up from $393 million in 2014 and $216 million in 2013.

Financial Performance

Increased sales of antiviral products have provided healthy revenue increases for Gilead in recent years. Overall revenue rose 31% to $32.6 billion in 2015, primarily due to a 32% increase in antiviral product sales. These were primarily driven by growing sales of new hepatitis treatment Harvoni, which was initially introduced in 2014 and then launched in Asia and Europe in 2015. Additionally, the company saw higher sales of its newer HIV single-tablet regiments Stribild and Complera/Eviplera. These gains were partially offset by lower sales of Sovaldi and Atripla, which have been losing ground to some of Gilead's new treatments. Altogether, product sales in the US rose 17% while product sales in Europe increased 39%.

Net income nearly tripled in 2014 and then rose another 50% to $18.1 billion in 2015, primarily as a result of the revenue growth. Cash flow from operations rose 59% to $20.3 billion in 2015, thanks to the higher net income as well as a decline in cash used in accounts receivable.


One of the pitfalls of the pharma manufacturing business is patent expirations, where older medications see a decline in sales as they begin to face generic competition. Other medications struggle to penetrate highly saturated markets. To offset potential losses from these challenges, Gilead is working to increase sales of top selling products in new territories. In addition, Gilead works to get existing medications approved for new medical indications.

The company also works to launch new or next-generation drugs to freshen its lineup of patent-protected offerings. The company's development programs include potential treatments for viral infections, liver disease, respiratory and cardiovascular ailments, and various cancers. Gilead also conducts R&D efforts through collaborations; for instance, it has a development partnership with Japan Tobacco on new HIV drugs.

Gilead continues to build up its existing portfolio through internal discovery and clinical development, as well as by acquiring or in-licensing products.

In 2014, the European Commission gave marketing approval for Zydelig (idelalisib), a treatment for incurable blood cancers chronic lymphocytic (CLL) leukemia and follicular lymphoma. Sovaldi was also given the go-ahead in Europe; the FDA granted approvals for Harvoni, Tybost, and Zydelig, for the treatment of hepatitis, HIV, and cancer, respectively. Harvoni was approved in Europe in 2014.

The following year, the FDA approved Genvoya for the treatment of HIV-1 infection. And in 2016, the company's Epclusa (a single-table regiment for adults with genotype 1-6 chronic hepatitis C), Descovy (a combination for the treatment of HIV), and Odefsey (for HIV-1) were given FDA approval.

The company is focused on expanding access to Sovaldi and Harvoni in the US, as well as launching Harvoni in additional markets in Europe and elsewhere. In 2014, Gilead signed licensing agreements with nine India-based generic pharmaceutical manufacturers to increase access to its chronic hepatitis C medications (including Sovaldi) in more than 90 developing nations. In 2015 the company received approval for Truvada in South Africa and Kenya; it received Canadian approval for the PrEP treatment (to help reduce the risk of getting HIV-1) in 2016.

Other partnerships entered into in 2014 were the license agreement with Ono Pharmaceutical to develop and commercialize GS-4059, a BTK inhibitor for the treatment of B-cell malignancies; and an agreement with Janssen R&D Ireland for the development of a new HIV treatment containing compounds from both companies. In 2016 Gilead partnered with Galapagos to develop and commercialize filgotinib, which is being investigated for inflammatory disease.

Mergers and Acquisitions

As yet another way of fending off losses from patent expirations, Gilead Sciences has diversified its product line through acquisitions.

In 2015, Gilead acquired EpiTherapeutics, a developer of novel cancer drugs based on epigenetics, for $65 million. In 2016 the company bought Nimbus Therapeutics subsidiary Nimbus Apollo for $400 million; the deal included Nimbus' Acetyl-CoA Carboxylase (ACC) inhibitor program for the treatment of liver disease.

Also in 2015, the company entered into an agreement with Phenex Pharmaceuticals in 2015; under the deal, Gilead acquired Phenex's FXR program for the treatment of liver diseases for some $470 million. That transaction accelerates Gilead's efforts to develop new treatments for fibrotic liver diseases.

- Show Less + Show Full Description

Company News and Press Releases

- Show Less + Show More News and Press Releases


333 Lakeside Dr
Foster City, CA 94404-1147
Phone: 1 (650) 574-3000
Fax: 1 (650) 578-9264


  • Employer Type: Public
  • Stock Symbol: GILD
  • Stock Exchange: NASDAQ
  • President and CEO: John F. Milligan
  • President and CEO: John F. Milligan
  • COO: Kevin Young
  • 2016 Employees: 9,000

Major Office Locations

  • Foster City, CA

Other Locations

  • Fremont, CA
  • Oceanside, CA
  • San Dimas, CA
  • Boulder, CO
  • Branford, CT
  • Seattle, WA
  • London, England
- Show Less + Show More